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The Replace Animal Tests Act of 2025 prohibits entities from submitting animal-derived test data to federal regulatory agencies (FDA, EPA, USDA, and CPSC) when scientifically satisfactory non-animal test methods are available and accepted by those agencies. The bill requires covered agencies to issue guidance on non-animal testing methods within one year, revise regulations to reflect their acceptability, and publish annual reports on animal and non-animal testing usage. When no appropriate non-animal alternative exists, the bill requires entities to minimize the number of animals used and reduce animal suffering.
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